Queroplex
Queroplex Brand names, Queroplex Analogs
Queroplex Brand Names Mixture
- No information avaliable
Queroplex Chemical_Formula
C4H3FN2O2
Queroplex RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Queroplex fda sheet
Queroplex msds (material safety sheet)
Queroplex Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Queroplex Molecular Weight
130.077 g/mol
Queroplex Melting Point
280-282oC
Queroplex H2O Solubility
< 0.1 g/100 mL at 19 °C
Queroplex State
Solid
Queroplex LogP
-0.77
Queroplex Dosage Forms
Topical preparations; Solution for injection
Queroplex Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Queroplex Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Queroplex Absorption
28-100%
Queroplex side effects and Toxicity
LD50=230mg/kg (orally in mice)
Queroplex Patient Information
Queroplex Organisms Affected
Humans and other mammals
