Fluracil
Fluracil Brand names, Fluracil Analogs
Fluracil Brand Names Mixture
- No information avaliable
Fluracil Chemical_Formula
C4H3FN2O2
Fluracil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluracil fda sheet
Fluracil msds (material safety sheet)
Fluracil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluracil Molecular Weight
130.077 g/mol
Fluracil Melting Point
280-282oC
Fluracil H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluracil State
Solid
Fluracil LogP
-0.77
Fluracil Dosage Forms
Topical preparations; Solution for injection
Fluracil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluracil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluracil Absorption
28-100%
Fluracil side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluracil Patient Information
Fluracil Organisms Affected
Humans and other mammals
