Fluril
Fluril Brand names, Fluril Analogs
Fluril Brand Names Mixture
- No information avaliable
Fluril Chemical_Formula
C4H3FN2O2
Fluril RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluril fda sheet
Fluril msds (material safety sheet)
Fluril Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluril Molecular Weight
130.077 g/mol
Fluril Melting Point
280-282oC
Fluril H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluril State
Solid
Fluril LogP
-0.77
Fluril Dosage Forms
Topical preparations; Solution for injection
Fluril Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluril Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluril Absorption
28-100%
Fluril side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluril Patient Information
Fluril Organisms Affected
Humans and other mammals
