Timazin
Timazin Brand names, Timazin Analogs
Timazin Brand Names Mixture
- No information avaliable
Timazin Chemical_Formula
C4H3FN2O2
Timazin RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Timazin fda sheet
Timazin msds (material safety sheet)
Timazin Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Timazin Molecular Weight
130.077 g/mol
Timazin Melting Point
280-282oC
Timazin H2O Solubility
< 0.1 g/100 mL at 19 °C
Timazin State
Solid
Timazin LogP
-0.77
Timazin Dosage Forms
Topical preparations; Solution for injection
Timazin Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Timazin Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Timazin Absorption
28-100%
Timazin side effects and Toxicity
LD50=230mg/kg (orally in mice)
Timazin Patient Information
Timazin Organisms Affected
Humans and other mammals
