Ulup
Ulup Brand names, Ulup Analogs
Ulup Brand Names Mixture
- No information avaliable
Ulup Chemical_Formula
C4H3FN2O2
Ulup RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Ulup fda sheet
Ulup msds (material safety sheet)
Ulup Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Ulup Molecular Weight
130.077 g/mol
Ulup Melting Point
280-282oC
Ulup H2O Solubility
< 0.1 g/100 mL at 19 °C
Ulup State
Solid
Ulup LogP
-0.77
Ulup Dosage Forms
Topical preparations; Solution for injection
Ulup Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Ulup Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Ulup Absorption
28-100%
Ulup side effects and Toxicity
LD50=230mg/kg (orally in mice)
Ulup Patient Information
Ulup Organisms Affected
Humans and other mammals
