Fluoroblastin
Fluoroblastin Brand names, Fluoroblastin Analogs
Fluoroblastin Brand Names Mixture
- No information avaliable
Fluoroblastin Chemical_Formula
C4H3FN2O2
Fluoroblastin RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluoroblastin fda sheet
Fluoroblastin msds (material safety sheet)
Fluoroblastin Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluoroblastin Molecular Weight
130.077 g/mol
Fluoroblastin Melting Point
280-282oC
Fluoroblastin H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluoroblastin State
Solid
Fluoroblastin LogP
-0.77
Fluoroblastin Dosage Forms
Topical preparations; Solution for injection
Fluoroblastin Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluoroblastin Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluoroblastin Absorption
28-100%
Fluoroblastin side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluoroblastin Patient Information
Fluoroblastin Organisms Affected
Humans and other mammals
