Kecimeton
Kecimeton Brand names, Kecimeton Analogs
Kecimeton Brand Names Mixture
- No information avaliable
Kecimeton Chemical_Formula
C4H3FN2O2
Kecimeton RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Kecimeton fda sheet
Kecimeton msds (material safety sheet)
Kecimeton Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Kecimeton Molecular Weight
130.077 g/mol
Kecimeton Melting Point
280-282oC
Kecimeton H2O Solubility
< 0.1 g/100 mL at 19 °C
Kecimeton State
Solid
Kecimeton LogP
-0.77
Kecimeton Dosage Forms
Topical preparations; Solution for injection
Kecimeton Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Kecimeton Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Kecimeton Absorption
28-100%
Kecimeton side effects and Toxicity
LD50=230mg/kg (orally in mice)
Kecimeton Patient Information
Kecimeton Organisms Affected
Humans and other mammals
