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Kecimeton Brand names, Kecimeton Analogs

Kecimeton Brand Names Mixture

  • No information avaliable

Kecimeton Chemical_Formula

C4H3FN2O2

Kecimeton RX_link

http://www.rxlist.com/cgi/generic3/carac.htm

Kecimeton fda sheet

Kecimeton FDA

Kecimeton msds (material safety sheet)

Kecimeton MSDS

Kecimeton Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Kecimeton Molecular Weight

130.077 g/mol

Kecimeton Melting Point

280-282oC

Kecimeton H2O Solubility

< 0.1 g/100 mL at 19 °C

Kecimeton State

Solid

Kecimeton LogP

-0.77

Kecimeton Dosage Forms

Topical preparations; Solution for injection

Kecimeton Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Kecimeton Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Kecimeton Absorption

28-100%

Kecimeton side effects and Toxicity

LD50=230mg/kg (orally in mice)

Kecimeton Patient Information

Kecimeton Organisms Affected

Humans and other mammals