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Efurix Brand names, Efurix Analogs

Efurix Brand Names Mixture

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Efurix Chemical_Formula


Efurix RX_link


Efurix fda sheet

Efurix FDA

Efurix msds (material safety sheet)

Efurix MSDS

Efurix Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Efurix Molecular Weight

130.077 g/mol

Efurix Melting Point


Efurix H2O Solubility

< 0.1 g/100 mL at 19 °C

Efurix State


Efurix LogP


Efurix Dosage Forms

Topical preparations; Solution for injection

Efurix Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Efurix Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Efurix Absorption


Efurix side effects and Toxicity

LD50=230mg/kg (orally in mice)

Efurix Patient Information

Efurix Organisms Affected

Humans and other mammals