Efurix
Efurix Brand names, Efurix Analogs
Efurix Brand Names Mixture
- No information avaliable
Efurix Chemical_Formula
C4H3FN2O2
Efurix RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Efurix fda sheet
Efurix msds (material safety sheet)
Efurix Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Efurix Molecular Weight
130.077 g/mol
Efurix Melting Point
280-282oC
Efurix H2O Solubility
< 0.1 g/100 mL at 19 °C
Efurix State
Solid
Efurix LogP
-0.77
Efurix Dosage Forms
Topical preparations; Solution for injection
Efurix Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Efurix Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Efurix Absorption
28-100%
Efurix side effects and Toxicity
LD50=230mg/kg (orally in mice)
Efurix Patient Information
Efurix Organisms Affected
Humans and other mammals
