Effluderm
Effluderm Brand names, Effluderm Analogs
Effluderm Brand Names Mixture
- No information avaliable
Effluderm Chemical_Formula
C4H3FN2O2
Effluderm RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Effluderm fda sheet
Effluderm msds (material safety sheet)
Effluderm Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Effluderm Molecular Weight
130.077 g/mol
Effluderm Melting Point
280-282oC
Effluderm H2O Solubility
< 0.1 g/100 mL at 19 °C
Effluderm State
Solid
Effluderm LogP
-0.77
Effluderm Dosage Forms
Topical preparations; Solution for injection
Effluderm Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Effluderm Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Effluderm Absorption
28-100%
Effluderm side effects and Toxicity
LD50=230mg/kg (orally in mice)
Effluderm Patient Information
Effluderm Organisms Affected
Humans and other mammals
