Efudex en es it fr

Efudex Brand names, Efudex Analogs

Efudex Brand Names Mixture

  • No information avaliable

Efudex Chemical_Formula


Efudex RX_link


Efudex fda sheet

Efudex FDA

Efudex msds (material safety sheet)

Efudex MSDS

Efudex Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Efudex Molecular Weight

130.077 g/mol

Efudex Melting Point


Efudex H2O Solubility

< 0.1 g/100 mL at 19 °C

Efudex State


Efudex LogP


Efudex Dosage Forms

Topical preparations; Solution for injection

Efudex Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Efudex Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Efudex Absorption


Efudex side effects and Toxicity

LD50=230mg/kg (orally in mice)

Efudex Patient Information

Efudex Organisms Affected

Humans and other mammals