Efudex
Efudex Brand names, Efudex Analogs
Efudex Brand Names Mixture
- No information avaliable
Efudex Chemical_Formula
C4H3FN2O2
Efudex RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Efudex fda sheet
Efudex msds (material safety sheet)
Efudex Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Efudex Molecular Weight
130.077 g/mol
Efudex Melting Point
280-282oC
Efudex H2O Solubility
< 0.1 g/100 mL at 19 °C
Efudex State
Solid
Efudex LogP
-0.77
Efudex Dosage Forms
Topical preparations; Solution for injection
Efudex Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Efudex Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Efudex Absorption
28-100%
Efudex side effects and Toxicity
LD50=230mg/kg (orally in mice)
Efudex Patient Information
Efudex Organisms Affected
Humans and other mammals
