Lipantil
Brand names,
Lipantil
Analogs
Lipantil
Brand Names Mixture
Lipantil
Chemical_Formula
C20H21ClO4
Lipantil
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Lipantil
fda sheet
Lipantil
msds (material safety sheet)
Lipantil
Synthesis Reference
No information avaliable
Lipantil
Molecular Weight
360.831 g/mol
Lipantil
Melting Point
80.5 °C
Lipantil
H2O Solubility
0.25mg/ml at 25 °C
Lipantil
State
Solid
Lipantil
LogP
5.575
Lipantil
Dosage Forms
Capsule; Tablet
Lipantil
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Lipantil
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Lipantil
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Lipantil
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Lipantil
Patient Information
No information avaliable
Lipantil
Organisms Affected
Humans and other mammals