Lofibra

Lofibra Brand names, Lofibra Analogs

Lofibra Brand Names Mixture

No information avaliable

Lofibra Chemical_Formula

C₂₀H₂₁ClO₄

Lofibra RX_link

http://www.rxlist.com/cgi/generic3/fenofibrate.htm

Lofibra fda sheet

Lofibra FDA

Lofibra msds (material safety sheet)

Lofibra MSDS

Lofibra Synthesis Reference

No information avaliable

Lofibra Molecular Weight

360.831 g/mol

Lofibra Melting Point

80.5 °C

Lofibra H₂O Solubility

0.25mg/ml at 25 °C

Lofibra State

Solid

Lofibra LogP

5.575

Lofibra Dosage Forms

Capsule; Tablet

Lofibra Indication

For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)

Lofibra Pharmacology

Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.

Lofibra Absorption

Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide

Lofibra side effects and Toxicity

LD₅₀=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.

Lofibra Patient Information