Fenobrate

Fenobrate Brand names, Fenobrate Analogs

Fenobrate Brand Names Mixture

No information avaliable

Fenobrate Chemical_Formula

C₂₀H₂₁ClO₄

Fenobrate RX_link

http://www.rxlist.com/cgi/generic3/fenofibrate.htm

Fenobrate fda sheet

Fenobrate FDA

Fenobrate msds (material safety sheet)

Fenobrate MSDS

Fenobrate Synthesis Reference

No information avaliable

Fenobrate Molecular Weight

360.831 g/mol

Fenobrate Melting Point

80.5 °C

Fenobrate H₂O Solubility

0.25mg/ml at 25 °C

Fenobrate State

Solid

Fenobrate LogP

5.575

Fenobrate Dosage Forms

Capsule; Tablet

Fenobrate Indication

For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)

Fenobrate Pharmacology

Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.

Fenobrate Absorption

Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide

Fenobrate side effects and Toxicity

LD₅₀=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.

Fenobrate Patient Information