Elasterin
Brand names,
Elasterin
Analogs
Elasterin
Brand Names Mixture
Elasterin
Chemical_Formula
C20H21ClO4
Elasterin
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Elasterin
fda sheet
Elasterin
msds (material safety sheet)
Elasterin
Synthesis Reference
No information avaliable
Elasterin
Molecular Weight
360.831 g/mol
Elasterin
Melting Point
80.5 °C
Elasterin
H2O Solubility
0.25mg/ml at 25 °C
Elasterin
State
Solid
Elasterin
LogP
5.575
Elasterin
Dosage Forms
Capsule; Tablet
Elasterin
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Elasterin
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Elasterin
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Elasterin
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Elasterin
Patient Information
No information avaliable
Elasterin
Organisms Affected
Humans and other mammals