Lipidil
Brand names,
Lipidil
Analogs
Lipidil
Brand Names Mixture
Lipidil
Chemical_Formula
C20H21ClO4
Lipidil
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Lipidil
fda sheet
Lipidil
msds (material safety sheet)
Lipidil
Synthesis Reference
No information avaliable
Lipidil
Molecular Weight
360.831 g/mol
Lipidil
Melting Point
80.5 °C
Lipidil
H2O Solubility
0.25mg/ml at 25 °C
Lipidil
State
Solid
Lipidil
LogP
5.575
Lipidil
Dosage Forms
Capsule; Tablet
Lipidil
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Lipidil
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Lipidil
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Lipidil
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Lipidil
Patient Information
No information avaliable
Lipidil
Organisms Affected
Humans and other mammals