Lipoclar
Brand names,
Lipoclar
Analogs
Lipoclar
Brand Names Mixture
Lipoclar
Chemical_Formula
C20H21ClO4
Lipoclar
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Lipoclar
fda sheet
Lipoclar
msds (material safety sheet)
Lipoclar
Synthesis Reference
No information avaliable
Lipoclar
Molecular Weight
360.831 g/mol
Lipoclar
Melting Point
80.5 °C
Lipoclar
H2O Solubility
0.25mg/ml at 25 °C
Lipoclar
State
Solid
Lipoclar
LogP
5.575
Lipoclar
Dosage Forms
Capsule; Tablet
Lipoclar
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Lipoclar
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Lipoclar
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Lipoclar
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Lipoclar
Patient Information
No information avaliable
Lipoclar
Organisms Affected
Humans and other mammals