Elasterate
Brand names,
Elasterate
Analogs
Elasterate
Brand Names Mixture
Elasterate
Chemical_Formula
C20H21ClO4
Elasterate
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Elasterate
fda sheet
Elasterate
msds (material safety sheet)
Elasterate
Synthesis Reference
No information avaliable
Elasterate
Molecular Weight
360.831 g/mol
Elasterate
Melting Point
80.5 °C
Elasterate
H2O Solubility
0.25mg/ml at 25 °C
Elasterate
State
Solid
Elasterate
LogP
5.575
Elasterate
Dosage Forms
Capsule; Tablet
Elasterate
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Elasterate
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Elasterate
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Elasterate
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Elasterate
Patient Information
No information avaliable
Elasterate
Organisms Affected
Humans and other mammals