Fenogal
Brand names,
Fenogal
Analogs
Fenogal
Brand Names Mixture
Fenogal
Chemical_Formula
C20H21ClO4
Fenogal
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Fenogal
fda sheet
Fenogal
msds (material safety sheet)
Fenogal
Synthesis Reference
No information avaliable
Fenogal
Molecular Weight
360.831 g/mol
Fenogal
Melting Point
80.5 °C
Fenogal
H2O Solubility
0.25mg/ml at 25 °C
Fenogal
State
Solid
Fenogal
LogP
5.575
Fenogal
Dosage Forms
Capsule; Tablet
Fenogal
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Fenogal
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Fenogal
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Fenogal
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Fenogal
Patient Information
No information avaliable
Fenogal
Organisms Affected
Humans and other mammals