Lipsin
Brand names,
Lipsin
Analogs
Lipsin
Brand Names Mixture
Lipsin
Chemical_Formula
C20H21ClO4
Lipsin
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Lipsin
fda sheet
Lipsin
msds (material safety sheet)
Lipsin
Synthesis Reference
No information avaliable
Lipsin
Molecular Weight
360.831 g/mol
Lipsin
Melting Point
80.5 °C
Lipsin
H2O Solubility
0.25mg/ml at 25 °C
Lipsin
State
Solid
Lipsin
LogP
5.575
Lipsin
Dosage Forms
Capsule; Tablet
Lipsin
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Lipsin
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Lipsin
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Lipsin
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Lipsin
Patient Information
No information avaliable
Lipsin
Organisms Affected
Humans and other mammals