Lipanthyl
Brand names,
Lipanthyl
Analogs
Lipanthyl
Brand Names Mixture
Lipanthyl
Chemical_Formula
C20H21ClO4
Lipanthyl
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Lipanthyl
fda sheet
Lipanthyl
msds (material safety sheet)
Lipanthyl
Synthesis Reference
No information avaliable
Lipanthyl
Molecular Weight
360.831 g/mol
Lipanthyl
Melting Point
80.5 °C
Lipanthyl
H2O Solubility
0.25mg/ml at 25 °C
Lipanthyl
State
Solid
Lipanthyl
LogP
5.575
Lipanthyl
Dosage Forms
Capsule; Tablet
Lipanthyl
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Lipanthyl
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Lipanthyl
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Lipanthyl
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Lipanthyl
Patient Information
No information avaliable
Lipanthyl
Organisms Affected
Humans and other mammals