Nolipax
Brand names,
Nolipax
Analogs
Nolipax
Brand Names Mixture
Nolipax
Chemical_Formula
C20H21ClO4
Nolipax
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Nolipax
fda sheet
Nolipax
msds (material safety sheet)
Nolipax
Synthesis Reference
No information avaliable
Nolipax
Molecular Weight
360.831 g/mol
Nolipax
Melting Point
80.5 °C
Nolipax
H2O Solubility
0.25mg/ml at 25 °C
Nolipax
State
Solid
Nolipax
LogP
5.575
Nolipax
Dosage Forms
Capsule; Tablet
Nolipax
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Nolipax
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Nolipax
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Nolipax
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Nolipax
Patient Information
No information avaliable
Nolipax
Organisms Affected
Humans and other mammals