Ankebin
Brand names,
Ankebin
Analogs
Ankebin
Brand Names Mixture
Ankebin
Chemical_Formula
C20H21ClO4
Ankebin
RX_link
http://www.rxlist.com/cgi/generic3/fenofibrate.htm
Ankebin
fda sheet
Ankebin
msds (material safety sheet)
Ankebin
Synthesis Reference
No information avaliable
Ankebin
Molecular Weight
360.831 g/mol
Ankebin
Melting Point
80.5 °C
Ankebin
H2O Solubility
0.25mg/ml at 25 °C
Ankebin
State
Solid
Ankebin
LogP
5.575
Ankebin
Dosage Forms
Capsule; Tablet
Ankebin
Indication
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Ankebin
Pharmacology
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Ankebin
Absorption
Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
Ankebin
side effects and Toxicity
LD50=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.
Ankebin
Patient Information
No information avaliable
Ankebin
Organisms Affected
Humans and other mammals