Kumader
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H16O4
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RX_link
http://www.rxlist.com/cgi/generic/warfarin.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Stahmann, et al., U.S. Pat. 2,427,578 (1947)
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Molecular Weight
308.328 g/mol
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Melting Point
161 oC
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H2O Solubility
17 mg/L
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State
Solid
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LogP
3.505
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Dosage Forms
Powder for solution; Tablet
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Indication
For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.
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Pharmacology
Warfarin, a coumarin anticoagulant, is a racemic mixture of two active isomers. It is used in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
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Absorption
No information avaliable
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side effects and Toxicity
LD50=374 (orally in mice)
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals