Coumafene
Brand names,
Coumafene
Analogs
Coumafene
Brand Names Mixture
Coumafene
Chemical_Formula
C19H16O4
Coumafene
RX_link
http://www.rxlist.com/cgi/generic/warfarin.htm
Coumafene
fda sheet
Coumafene
msds (material safety sheet)
Coumafene
Synthesis Reference
Stahmann, et al., U.S. Pat. 2,427,578 (1947)
Coumafene
Molecular Weight
308.328 g/mol
Coumafene
Melting Point
161 oC
Coumafene
H2O Solubility
17 mg/L
Coumafene
State
Solid
Coumafene
LogP
3.505
Coumafene
Dosage Forms
Powder for solution; Tablet
Coumafene
Indication
For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.
Coumafene
Pharmacology
Warfarin, a coumarin anticoagulant, is a racemic mixture of two active isomers. It is used in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
Coumafene
Absorption
No information avaliable
Coumafene
side effects and Toxicity
LD50=374 (orally in mice)
Coumafene
Patient Information
No information avaliable
Coumafene
Organisms Affected
Humans and other mammals