Coumefene
Brand names,
Coumefene
Analogs
Coumefene
Brand Names Mixture
Coumefene
Chemical_Formula
C19H16O4
Coumefene
RX_link
http://www.rxlist.com/cgi/generic/warfarin.htm
Coumefene
fda sheet
Coumefene
msds (material safety sheet)
Coumefene
Synthesis Reference
Stahmann, et al., U.S. Pat. 2,427,578 (1947)
Coumefene
Molecular Weight
308.328 g/mol
Coumefene
Melting Point
161 oC
Coumefene
H2O Solubility
17 mg/L
Coumefene
State
Solid
Coumefene
LogP
3.505
Coumefene
Dosage Forms
Powder for solution; Tablet
Coumefene
Indication
For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.
Coumefene
Pharmacology
Warfarin, a coumarin anticoagulant, is a racemic mixture of two active isomers. It is used in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
Coumefene
Absorption
No information avaliable
Coumefene
side effects and Toxicity
LD50=374 (orally in mice)
Coumefene
Patient Information
No information avaliable
Coumefene
Organisms Affected
Humans and other mammals