Coumarins
Brand names,
Coumarins
Analogs
Coumarins
Brand Names Mixture
Coumarins
Chemical_Formula
C19H16O4
Coumarins
RX_link
http://www.rxlist.com/cgi/generic/warfarin.htm
Coumarins
fda sheet
Coumarins
msds (material safety sheet)
Coumarins
Synthesis Reference
Stahmann, et al., U.S. Pat. 2,427,578 (1947)
Coumarins
Molecular Weight
308.328 g/mol
Coumarins
Melting Point
161 oC
Coumarins
H2O Solubility
17 mg/L
Coumarins
State
Solid
Coumarins
LogP
3.505
Coumarins
Dosage Forms
Powder for solution; Tablet
Coumarins
Indication
For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.
Coumarins
Pharmacology
Warfarin, a coumarin anticoagulant, is a racemic mixture of two active isomers. It is used in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
Coumarins
Absorption
No information avaliable
Coumarins
side effects and Toxicity
LD50=374 (orally in mice)
Coumarins
Patient Information
No information avaliable
Coumarins
Organisms Affected
Humans and other mammals