Fluorouracil en es it fr

Fluorouracil Brand names, Fluorouracil Analogs

Fluorouracil Brand Names Mixture

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Fluorouracil Chemical_Formula


Fluorouracil RX_link


Fluorouracil fda sheet

Fluorouracil FDA

Fluorouracil msds (material safety sheet)

Fluorouracil MSDS

Fluorouracil Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Fluorouracil Molecular Weight

130.077 g/mol

Fluorouracil Melting Point


Fluorouracil H2O Solubility

< 0.1 g/100 mL at 19 °C

Fluorouracil State


Fluorouracil LogP


Fluorouracil Dosage Forms

Topical preparations; Solution for injection

Fluorouracil Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Fluorouracil Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Fluorouracil Absorption


Fluorouracil side effects and Toxicity

LD50=230mg/kg (orally in mice)

Fluorouracil Patient Information

Fluorouracil Organisms Affected

Humans and other mammals