Fluorouracil
Fluorouracil Brand names, Fluorouracil Analogs
Fluorouracil Brand Names Mixture
- No information avaliable
Fluorouracil Chemical_Formula
C4H3FN2O2
Fluorouracil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
Fluorouracil fda sheet
Fluorouracil msds (material safety sheet)
Fluorouracil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
Fluorouracil Molecular Weight
130.077 g/mol
Fluorouracil Melting Point
280-282oC
Fluorouracil H2O Solubility
< 0.1 g/100 mL at 19 °C
Fluorouracil State
Solid
Fluorouracil LogP
-0.77
Fluorouracil Dosage Forms
Topical preparations; Solution for injection
Fluorouracil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Fluorouracil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Fluorouracil Absorption
28-100%
Fluorouracil side effects and Toxicity
LD50=230mg/kg (orally in mice)
Fluorouracil Patient Information
Fluorouracil Organisms Affected
Humans and other mammals
