Safety (MSDS) data for 5-fluorouracil

Safety (MSDS) data for 5-fluorouracil

Hazard: harmful


    Synonyms: fluorouracil, 5-FU, FU, 5-fluoro-2,4(1H,3H)-pyrimidinedione, timazin, adrucil, carzonal, efudex, efudix, fluoroblastin, queroplex, many other trade names.
    Use: Anti-cancer drug
    Molecular formula: C4H3FN2O2
    CAS No: 51-21-8
    EINECS No: 200-085-6

Physical data

    Appearance: white crystals or powder
    Melting point: ca. 280 C (decomposes) [sublimes at ca. 195 C]
    Boiling point:
    Vapour density:
    Vapour pressure:
    Density (g cm-3):
    Flash point:
    Explosion limits:
    Autoignition temperature:
    Water solubility:


    Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.


    Harmful by ingestion, may be harmful by inhalation or through skin contact. Experimental mutagen in laboratory animals. May cause reproductive disorders. Suspected human carcinogen. May cause systemic effects. Irritant.

    Toxicity data
    (The meaning of any abbreviations which appear in this section is given here.)
    IPN-RAT LD50 230 mg kg-1
    ORL-MUS LD50 115 mg kg-1
    ORL-HMN LDLO 450 mg kg-1 / 30d
    ORL-RAT LD50 230 mg kg-1
    IVN-RAT LD50 245 mg kg-1
    SCN-MUS LD50 169 mg kg-1

    Risk phrases
    (The meaning of any risk phrases which appear in this section is given here.)
    R22 R40 R47.

Transport information

Personal protection

    Safety glasses, adequate ventilation.

[Return to Physical & Theoretical Chemistry Lab. Safety home page.]

This information was last updated on April 19, 2005. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. We have not verified this information, and cannot guarantee that it is up-to-date.