Safety (MSDS) data for pyrimethamine

Safety (MSDS) data for pyrimethamine

Hazard: harmful


    Synonyms: 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine, CD, chloridin, chloridine, chloridyn, darachlor, darapram, daraprim, daraprime, diaminopyritamin, erbaprelina, malocide, maloprim, pirimecidan, tindurin, malacid, further trade names
    Use: antimalarial drug, veterinary drug
    Molecular formula: C12H13ClN4
    CAS No: 58-14-0
    EINECS No:

Physical data

    Appearance: white powder
    Melting point: 233 C
    Boiling point:
    Vapour density:
    Vapour pressure:
    Density (g cm-3):
    Flash point:
    Explosion limits:
    Autoignition temperature:
    Water solubility: negligible


    Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.


    Poison. Experimental teratogen. Human mutagenic data. May cause reproductive harm.

    Toxicity data
    (The meaning of any toxicological abbreviations which appear in this section is given here.)
    ORL-MUS LD50 92 mg kg-1
    IPR-MUS LD50 74 mg kg-1
    ORL-HAM LDLO 250 mg kg-1
    SCU-MUS LDLO 160 mg kg-1

    Risk phrases
    (The meaning of any risk phrases which appear in this section is given here.)
    R23 R24 R25.

Transport information

    (The meaning of any UN hazard codes which appear in this section is given here.)
    UN No 2811. Hazard class 6.1. Packing group III.

Personal protection

    Safety glasses, gloves, good ventilation.

    Safety phrases
    (The meaning of any safety phrases which appear in this section is given here.)

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This information was last updated on August 24, 2005. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. We have not verified this information, and cannot guarantee that it is up-to-date.