Temetid
Brand names,
Temetid
Analogs
Temetid
Brand Names Mixture
Temetid
Chemical_Formula
C20H24ClN3S
Temetid
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Temetid
Molecular Weight
373.943 g/mol
Temetid
Melting Point
228oC
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H2O Solubility
Very slightly soluble
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State
Solid
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LogP
4.99
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Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Temetid
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Temetid
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Temetid
Absorption
Rapidly absorbed following oral administration
Temetid
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Temetid
Patient Information
Temetid
Organisms Affected
Humans and other mammals