Capazine
Brand names,
Capazine
Analogs
Capazine
Brand Names Mixture
Capazine
Chemical_Formula
C20H24ClN3S
Capazine
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Capazine
fda sheet
Capazine
msds (material safety sheet)
Capazine
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Capazine
Molecular Weight
373.943 g/mol
Capazine
Melting Point
228oC
Capazine
H2O Solubility
Very slightly soluble
Capazine
State
Solid
Capazine
LogP
4.99
Capazine
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Capazine
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Capazine
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Capazine
Absorption
Rapidly absorbed following oral administration
Capazine
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Capazine
Patient Information
Capazine
Organisms Affected
Humans and other mammals