Emetiral
Brand names,
Emetiral
Analogs
Emetiral
Brand Names Mixture
Emetiral
Chemical_Formula
C20H24ClN3S
Emetiral
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Emetiral
fda sheet
Emetiral
msds (material safety sheet)
Emetiral
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Emetiral
Molecular Weight
373.943 g/mol
Emetiral
Melting Point
228oC
Emetiral
H2O Solubility
Very slightly soluble
Emetiral
State
Solid
Emetiral
LogP
4.99
Emetiral
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Emetiral
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Emetiral
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Emetiral
Absorption
Rapidly absorbed following oral administration
Emetiral
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Emetiral
Patient Information
Emetiral
Organisms Affected
Humans and other mammals