Bayer A 173
Brand names,
Bayer A 173
Analogs
Bayer A 173
Brand Names Mixture
Bayer A 173
Chemical_Formula
C20H24ClN3S
Bayer A 173
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Bayer A 173
fda sheet
Bayer A 173
msds (material safety sheet)
Bayer A 173
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Bayer A 173
Molecular Weight
373.943 g/mol
Bayer A 173
Melting Point
228oC
Bayer A 173
H2O Solubility
Very slightly soluble
Bayer A 173
State
Solid
Bayer A 173
LogP
4.99
Bayer A 173
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Bayer A 173
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Bayer A 173
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Bayer A 173
Absorption
Rapidly absorbed following oral administration
Bayer A 173
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Bayer A 173
Patient Information
Bayer A 173
Organisms Affected
Humans and other mammals