Compazine
Brand names,
Compazine
Analogs
Compazine
Brand Names Mixture
Compazine
Chemical_Formula
C20H24ClN3S
Compazine
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Compazine
fda sheet
Compazine
msds (material safety sheet)
Compazine
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Compazine
Molecular Weight
373.943 g/mol
Compazine
Melting Point
228oC
Compazine
H2O Solubility
Very slightly soluble
Compazine
State
Solid
Compazine
LogP
4.99
Compazine
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Compazine
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Compazine
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Compazine
Absorption
Rapidly absorbed following oral administration
Compazine
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Compazine
Patient Information
Compazine
Organisms Affected
Humans and other mammals