Meterazin
Brand names,
Meterazin
Analogs
Meterazin
Brand Names Mixture
Meterazin
Chemical_Formula
C20H24ClN3S
Meterazin
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Meterazin
fda sheet
Meterazin
msds (material safety sheet)
Meterazin
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Meterazin
Molecular Weight
373.943 g/mol
Meterazin
Melting Point
228oC
Meterazin
H2O Solubility
Very slightly soluble
Meterazin
State
Solid
Meterazin
LogP
4.99
Meterazin
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Meterazin
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Meterazin
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Meterazin
Absorption
Rapidly absorbed following oral administration
Meterazin
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Meterazin
Patient Information
Meterazin
Organisms Affected
Humans and other mammals