Prochlorperazine maleate
Brand names,
Prochlorperazine maleate
Analogs
Prochlorperazine maleate
Brand Names Mixture
Prochlorperazine maleate
Chemical_Formula
C20H24ClN3S
Prochlorperazine maleate
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Prochlorperazine maleate
fda sheet
Prochlorperazine maleate
msds (material safety sheet)
Prochlorperazine maleate
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Prochlorperazine maleate
Molecular Weight
373.943 g/mol
Prochlorperazine maleate
Melting Point
228oC
Prochlorperazine maleate
H2O Solubility
Very slightly soluble
Prochlorperazine maleate
State
Solid
Prochlorperazine maleate
LogP
4.99
Prochlorperazine maleate
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Prochlorperazine maleate
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Prochlorperazine maleate
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Prochlorperazine maleate
Absorption
Rapidly absorbed following oral administration
Prochlorperazine maleate
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Prochlorperazine maleate
Patient Information
Prochlorperazine maleate
Organisms Affected
Humans and other mammals