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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C20H24ClN3S
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RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
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Molecular Weight
373.943 g/mol
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Melting Point
228oC
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H2O Solubility
Very slightly soluble
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State
Solid
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LogP
4.99
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Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
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Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
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Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
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Absorption
Rapidly absorbed following oral administration
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side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
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Patient Information
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Organisms Affected
Humans and other mammals