Buccastem
Brand names,
Buccastem
Analogs
Buccastem
Brand Names Mixture
Buccastem
Chemical_Formula
C20H24ClN3S
Buccastem
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Buccastem
fda sheet
Buccastem
msds (material safety sheet)
Buccastem
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Buccastem
Molecular Weight
373.943 g/mol
Buccastem
Melting Point
228oC
Buccastem
H2O Solubility
Very slightly soluble
Buccastem
State
Solid
Buccastem
LogP
4.99
Buccastem
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Buccastem
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Buccastem
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Buccastem
Absorption
Rapidly absorbed following oral administration
Buccastem
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Buccastem
Patient Information
Buccastem
Organisms Affected
Humans and other mammals