Prochlorpromazine
Brand names,
Prochlorpromazine
Analogs
Prochlorpromazine
Brand Names Mixture
Prochlorpromazine
Chemical_Formula
C20H24ClN3S
Prochlorpromazine
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Prochlorpromazine
fda sheet
Prochlorpromazine
msds (material safety sheet)
Prochlorpromazine
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Prochlorpromazine
Molecular Weight
373.943 g/mol
Prochlorpromazine
Melting Point
228oC
Prochlorpromazine
H2O Solubility
Very slightly soluble
Prochlorpromazine
State
Solid
Prochlorpromazine
LogP
4.99
Prochlorpromazine
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Prochlorpromazine
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Prochlorpromazine
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Prochlorpromazine
Absorption
Rapidly absorbed following oral administration
Prochlorpromazine
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Prochlorpromazine
Patient Information
Prochlorpromazine
Organisms Affected
Humans and other mammals