Chlormeprazine
Brand names,
Chlormeprazine
Analogs
Chlormeprazine
Brand Names Mixture
Chlormeprazine
Chemical_Formula
C20H24ClN3S
Chlormeprazine
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Chlormeprazine
fda sheet
Chlormeprazine
msds (material safety sheet)
Chlormeprazine
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Chlormeprazine
Molecular Weight
373.943 g/mol
Chlormeprazine
Melting Point
228oC
Chlormeprazine
H2O Solubility
Very slightly soluble
Chlormeprazine
State
Solid
Chlormeprazine
LogP
4.99
Chlormeprazine
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Chlormeprazine
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Chlormeprazine
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Chlormeprazine
Absorption
Rapidly absorbed following oral administration
Chlormeprazine
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Chlormeprazine
Patient Information
Chlormeprazine
Organisms Affected
Humans and other mammals