Prochlorperazine edisylate
Brand names,
Prochlorperazine edisylate
Analogs
Prochlorperazine edisylate
Brand Names Mixture
Prochlorperazine edisylate
Chemical_Formula
C20H24ClN3S
Prochlorperazine edisylate
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Prochlorperazine edisylate
fda sheet
Prochlorperazine edisylate
msds (material safety sheet)
Prochlorperazine edisylate
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Prochlorperazine edisylate
Molecular Weight
373.943 g/mol
Prochlorperazine edisylate
Melting Point
228oC
Prochlorperazine edisylate
H2O Solubility
Very slightly soluble
Prochlorperazine edisylate
State
Solid
Prochlorperazine edisylate
LogP
4.99
Prochlorperazine edisylate
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Prochlorperazine edisylate
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Prochlorperazine edisylate
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Prochlorperazine edisylate
Absorption
Rapidly absorbed following oral administration
Prochlorperazine edisylate
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Prochlorperazine edisylate
Patient Information
Prochlorperazine edisylate
Organisms Affected
Humans and other mammals