Eskatrol
Brand names,
Eskatrol
Analogs
Eskatrol
Brand Names Mixture
Eskatrol
Chemical_Formula
C20H24ClN3S
Eskatrol
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Eskatrol
fda sheet
Eskatrol
msds (material safety sheet)
Eskatrol
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Eskatrol
Molecular Weight
373.943 g/mol
Eskatrol
Melting Point
228oC
Eskatrol
H2O Solubility
Very slightly soluble
Eskatrol
State
Solid
Eskatrol
LogP
4.99
Eskatrol
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Eskatrol
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Eskatrol
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Eskatrol
Absorption
Rapidly absorbed following oral administration
Eskatrol
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Eskatrol
Patient Information
Eskatrol
Organisms Affected
Humans and other mammals