Meterazine
Brand names,
Meterazine
Analogs
Meterazine
Brand Names Mixture
Meterazine
Chemical_Formula
C20H24ClN3S
Meterazine
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Meterazine
fda sheet
Meterazine
msds (material safety sheet)
Meterazine
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Meterazine
Molecular Weight
373.943 g/mol
Meterazine
Melting Point
228oC
Meterazine
H2O Solubility
Very slightly soluble
Meterazine
State
Solid
Meterazine
LogP
4.99
Meterazine
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Meterazine
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Meterazine
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Meterazine
Absorption
Rapidly absorbed following oral administration
Meterazine
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Meterazine
Patient Information
Meterazine
Organisms Affected
Humans and other mammals