Meterazin Maleate
Brand names,
Meterazin Maleate
Analogs
Meterazin Maleate
Brand Names Mixture
Meterazin Maleate
Chemical_Formula
C20H24ClN3S
Meterazin Maleate
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Meterazin Maleate
fda sheet
Meterazin Maleate
msds (material safety sheet)
Meterazin Maleate
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Meterazin Maleate
Molecular Weight
373.943 g/mol
Meterazin Maleate
Melting Point
228oC
Meterazin Maleate
H2O Solubility
Very slightly soluble
Meterazin Maleate
State
Solid
Meterazin Maleate
LogP
4.99
Meterazin Maleate
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Meterazin Maleate
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Meterazin Maleate
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Meterazin Maleate
Absorption
Rapidly absorbed following oral administration
Meterazin Maleate
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Meterazin Maleate
Patient Information
Meterazin Maleate
Organisms Affected
Humans and other mammals