Kronocin
Brand names,
Kronocin
Analogs
Kronocin
Brand Names Mixture
Kronocin
Chemical_Formula
C20H24ClN3S
Kronocin
RX_link
http://www.rxlist.com/cgi/generic/prochlr.htm
Kronocin
fda sheet
Kronocin
msds (material safety sheet)
Kronocin
Synthesis Reference
R. J. Horclois, U.S. Pat. 2,902,484 (1959)
Kronocin
Molecular Weight
373.943 g/mol
Kronocin
Melting Point
228oC
Kronocin
H2O Solubility
Very slightly soluble
Kronocin
State
Solid
Kronocin
LogP
4.99
Kronocin
Dosage Forms
Tablet; Spansule; Capsule; Vial; Suppository; Syrup
Kronocin
Indication
For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders.
Kronocin
Pharmacology
Prochlorperazine is a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine. It shares many of the actions and adverse effects of the antipsychotics.
Kronocin
Absorption
Rapidly absorbed following oral administration
Kronocin
side effects and Toxicity
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
Kronocin
Patient Information
Kronocin
Organisms Affected
Humans and other mammals