Spirofulvin
Spirofulvin Brand names, Spirofulvin Analogs
- Amudane
- Biogrisin-fp
- Curling factor
- Delmofulvina
- Fulcin
- Fulcine
- Fulvican grisactin
- Fulvicin
- Fulvicin P/G
- Fulvicin U/F
- Fulvicin-P/G
- Fulvicin-U/F
- Fulvina
- Fulvinil
- Fulvistatin
- Fungivin
- Greosin
- Gresfeed
- Gricin
- Grifulin
- Grifulvin
- Grifulvin V
- Gris-PEG
- Grisactin
- Grisactin Ultra
- Griscofulvin
- Grisefuline
- Griseo
- Griseofulvin [USAN:BAN:INN:JAN]
- Griseofulvin forte
- Griseofulvin-forte
- Griseofulvina [INN-Spanish]
- Griseofulvine [INN-French]
- Griseofulvinum
- Griseofulvinum [INN-Latin]
- Griseomix
- Grisetin
- Grisofulvin
- Grisovin
- Grisovin FP
- Grizeofulvin
- Grysio
- Guservin
- Lamoryl
- Likuden
- Likunden
- Murfulvin
- Neo-Fulcin
- Neocid
- Poncyl
- Spirofulvin
- Sporostatin
- Sporostatin xan
- Xuanjing
Spirofulvin Brand Names Mixture
- No information avaliable
Spirofulvin Chemical_Formula
C17H17ClO6
Spirofulvin RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Spirofulvin fda sheet
Spirofulvin msds (material safety sheet)
Spirofulvin Synthesis Reference
No information avaliable
Spirofulvin Molecular Weight
352.766 g/mol
Spirofulvin Melting Point
220 oC
Spirofulvin H2O Solubility
8.64 mg/L
Spirofulvin State
Solid
Spirofulvin LogP
2.15
Spirofulvin Dosage Forms
Powder; Tablet
Spirofulvin Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Spirofulvin Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Spirofulvin Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Spirofulvin side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Spirofulvin Patient Information
Spirofulvin Organisms Affected
Yeast and other Trichophyton or Microsporum fungi
