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Spirofulvin Brand names, Spirofulvin Analogs

Spirofulvin Brand Names Mixture

  • No information avaliable

Spirofulvin Chemical_Formula


Spirofulvin RX_link


Spirofulvin fda sheet

Spirofulvin msds (material safety sheet)

Spirofulvin MSDS

Spirofulvin Synthesis Reference

No information avaliable

Spirofulvin Molecular Weight

352.766 g/mol

Spirofulvin Melting Point

220 oC

Spirofulvin H2O Solubility

8.64 mg/L

Spirofulvin State


Spirofulvin LogP


Spirofulvin Dosage Forms

Powder; Tablet

Spirofulvin Indication

For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.

Spirofulvin Pharmacology

Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.

Spirofulvin Absorption

Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.

Spirofulvin side effects and Toxicity

Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions

Spirofulvin Patient Information

Spirofulvin Organisms Affected

Yeast and other Trichophyton or Microsporum fungi