Curling factor
Brand names,
Curling factor
Analogs
Curling factor
Brand Names Mixture
Curling factor
Chemical_Formula
C17H17ClO6
Curling factor
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Curling factor
fda sheet
Curling factor
msds (material safety sheet)
Curling factor
Synthesis Reference
No information avaliable
Curling factor
Molecular Weight
352.766 g/mol
Curling factor
Melting Point
220 oC
Curling factor
H2O Solubility
8.64 mg/L
Curling factor
State
Solid
Curling factor
LogP
2.15
Curling factor
Dosage Forms
Powder; Tablet
Curling factor
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Curling factor
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Curling factor
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Curling factor
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Curling factor
Patient Information
Curling factor
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi