Poncyl
Brand names,
Poncyl
Analogs
Poncyl
Brand Names Mixture
Poncyl
Chemical_Formula
C17H17ClO6
Poncyl
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Poncyl
fda sheet
Poncyl
msds (material safety sheet)
Poncyl
Synthesis Reference
No information avaliable
Poncyl
Molecular Weight
352.766 g/mol
Poncyl
Melting Point
220 oC
Poncyl
H2O Solubility
8.64 mg/L
Poncyl
State
Solid
Poncyl
LogP
2.15
Poncyl
Dosage Forms
Powder; Tablet
Poncyl
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Poncyl
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Poncyl
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Poncyl
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Poncyl
Patient Information
Poncyl
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi