Fulvican grisactin
Brand names,
Fulvican grisactin
Analogs
Fulvican grisactin
Brand Names Mixture
Fulvican grisactin
Chemical_Formula
C17H17ClO6
Fulvican grisactin
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Fulvican grisactin
fda sheet
Fulvican grisactin
msds (material safety sheet)
Fulvican grisactin
Synthesis Reference
No information avaliable
Fulvican grisactin
Molecular Weight
352.766 g/mol
Fulvican grisactin
Melting Point
220 oC
Fulvican grisactin
H2O Solubility
8.64 mg/L
Fulvican grisactin
State
Solid
Fulvican grisactin
LogP
2.15
Fulvican grisactin
Dosage Forms
Powder; Tablet
Fulvican grisactin
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Fulvican grisactin
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Fulvican grisactin
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Fulvican grisactin
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Fulvican grisactin
Patient Information
Fulvican grisactin
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi