Lamoryl
Brand names,
Lamoryl
Analogs
Lamoryl
Brand Names Mixture
Lamoryl
Chemical_Formula
C17H17ClO6
Lamoryl
RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Lamoryl
fda sheet
Lamoryl
msds (material safety sheet)
Lamoryl
Synthesis Reference
No information avaliable
Lamoryl
Molecular Weight
352.766 g/mol
Lamoryl
Melting Point
220 oC
Lamoryl
H2O Solubility
8.64 mg/L
Lamoryl
State
Solid
Lamoryl
LogP
2.15
Lamoryl
Dosage Forms
Powder; Tablet
Lamoryl
Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Lamoryl
Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Lamoryl
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Lamoryl
side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Lamoryl
Patient Information
Lamoryl
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi